Author: Umesh Devappa Suranagi; Harmeet Singh Rehan; Nitesh Goyal
Title: Hydroxychloroquine for the management of COVID-19: Hope or Hype? A Systematic review of the current evidence Document date: 2020_4_22
ID: 0u4ar3b5_26
Snippet: The in-vitro cell culture based data of viral inhibition does not suffice for the use of hydroxychloroquine in the patients with COVID-19. Current literature shows scant and low level evidence in human studies. Understandably due to the urgency and unmet need of the pandemic, various expert guidance and consensus statements recommend the empirical use of HCQ. However, at this stage due to insufficient evidence on efficacy and safety, it is reason.....
Document: The in-vitro cell culture based data of viral inhibition does not suffice for the use of hydroxychloroquine in the patients with COVID-19. Current literature shows scant and low level evidence in human studies. Understandably due to the urgency and unmet need of the pandemic, various expert guidance and consensus statements recommend the empirical use of HCQ. However, at this stage due to insufficient evidence on efficacy and safety, it is reasonable to suggest against the use HCQ as prophylaxis both in general population as well as health care workers. Considering the toxicity profile, chances of overdoses and poisoning can pose serious health threats if HCQ is used widely. Ongoing well designed clinical trials are expected to provide explicit answer in near future. All rights reserved. No reuse allowed without permission. author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
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