Author: Zingaropoli, Maria Antonella; Perri, Valentina; Pasculli, Patrizia; Dezza, Francesco Cogliati; Nijhawan, Parni; Savelloni, Giulia; La Torre, Giuseppe; D'Agostino, Claudia; Mengoni, Fabio; Lichtner, Miriam; Ciardi, Maria Rosa; Mastroianni, Claudio Maria
Title: Major reduction of NKT cells in patients with severe COVID-19 pneumonia Cord-id: w3pk3ha1 Document date: 2020_11_13
ID: w3pk3ha1
Snippet: Background: NK cells seem to be mainly involved in COVID-19 pneumonia. Little is known about NKT cells which represent a bridge between innate and adaptive immunity. Methods: We characterized peripheral blood T, NK and NKT cells in 45 patients with COVID-19 pneumonia (COVID-19 subjects) and 19 healthy donors (HDs). According to the severity of the disease, we stratified COVID-19 subjects into severe and non-severe groups. Results: Compared to HDs, COVID-19 subjects showed higher percentages of N
Document: Background: NK cells seem to be mainly involved in COVID-19 pneumonia. Little is known about NKT cells which represent a bridge between innate and adaptive immunity. Methods: We characterized peripheral blood T, NK and NKT cells in 45 patients with COVID-19 pneumonia (COVID-19 subjects) and 19 healthy donors (HDs). According to the severity of the disease, we stratified COVID-19 subjects into severe and non-severe groups. Results: Compared to HDs, COVID-19 subjects showed higher percentages of NK CD57+ and CD56dim NK cells and lower percentages of NKT and CD56bright cells. In the severe group we found a significantly lower percentage of NKT cells. In a multiple logistic regression analysis, NKT cell was independently associated with the severity of the disease. Conclusions: The low percentage of NKT cells in peripheral blood of COVID-19 subjects and the independent association with the severity of the disease suggests a potential role of this subset.
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