Coronavirus Infection and PARP Expression Dysregulate the NAD Metabolome: A Potentially Actionable Component of Innate Immunity

Collin D. Heer; Daniel J. Sanderson; Yousef M.O. Alhammad; Mark S. Schmidt; Samuel A.J. Trammell; Stanley Perlman; Michael S. Cohen; Anthony R. Fehr; Charles Brenner

. CC-BY-ND 4.0 International license author/funder. It is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi. org/10.1101 org/10. /2020 Multiple studies have shown that CARH is a prominent virulence factor and is critical to prevent PARP-mediated inhibition of virus replication and induction of a robust innate immune response (Eriksson et al., 2008; Fehr et al., 2016; Grunewald et al., 2019) . Due to the importance of NAD + levels for maximal PARP activity, we suggest that pharmacological targeting of CARH along and boosting the cytosolic NAD metabolome to promote PARP functions are potentially useful preventative approaches.