Author: Collin D. Heer; Daniel J. Sanderson; Yousef M.O. Alhammad; Mark S. Schmidt; Samuel A.J. Trammell; Stanley Perlman; Michael S. Cohen; Anthony R. Fehr; Charles Brenner
Title: Coronavirus Infection and PARP Expression Dysregulate the NAD Metabolome: A Potentially Actionable Component of Innate Immunity Document date: 2020_4_18
ID: 033phqmd_4
Snippet: However, most other members of the PARP superfamily possess monoADP-ribosyl (MARylating) transfer activities on target proteins (Cohen, 2020) . We showed that MHV infection strongly induces expression of PARP7, PARP9, PARP10, PARP11, PARP12, PARP13, and PARP14 (Grunewald et al., 2019) . To determine whether these gene expression changes are incidental to MHV infection, facilitate MHV infection, or are part of an innate immune response against MHV.....
Document: However, most other members of the PARP superfamily possess monoADP-ribosyl (MARylating) transfer activities on target proteins (Cohen, 2020) . We showed that MHV infection strongly induces expression of PARP7, PARP9, PARP10, PARP11, PARP12, PARP13, and PARP14 (Grunewald et al., 2019) . To determine whether these gene expression changes are incidental to MHV infection, facilitate MHV infection, or are part of an innate immune response against MHV, we treated cells with siRNAs to knock down expression of these gene and then analyzed the impact on MHV replication. Our data showed that PARP7 plays a role in facilitating replication. In contrast, PARP14 is required for full induction of IFN-b expression (Grunewald et al., 2019; Grunewald, Shaban, Mackin, Fehr, & Perlman, 2020) , suggesting PARP14 is directly involved in establishing the innate immune response in CoV infected cells.
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