Human leukocyte antigen susceptibility map for SARS-CoV-2

Austin Nguyen; Julianne K David; Sean K Maden; Mary A Wood; Benjamin R Weeder; Abhinav Nellore; Reid F Thompson

is the (which was not peer-reviewed) The copyright holder for this preprint . https://doi.org/10.1101/2020.03.22.20040600 doi: medRxiv preprint Supplementary Figure S8 : Distribution of HLA allelic presentation of 8-to 12-mers from the SARS-CoV proteome using the tool MHCflurry. At right, the number of peptides (see Supplementary Table S8 ) that putatively bind to each of 66 HLA alleles is shown as a series of horizontal bars, with dark and light shading indicating the number of tightly (<50nM) and loosely (<500nM) binding peptides respectively, and with green, orange, and purple colors representing HLA-A, -B, and -C alleles, respectively. Alleles are sorted in descending order based on the number of peptides they bind (<500nM). The corresponding estimated allelic frequency in the global population is also shown (to left), with length of horizontal bar indicating absolute frequency in the population.