Selected article for: "altered function and cell function"
Author: Alarcon, Pablo C.; Damen, Michelle S.M.A.; Madan, Rajat; Deepe, George S.; Spearman, Paul; Way, Sing Sing; Divanovic, Senad
Title: Adipocyte inflammation and pathogenesis of viral pneumonias: an overlooked contribution
  • Cord-id: y3gq8t41
  • Document date: 2021_5_6
    • ID: y3gq8t41
    Snippet: Epidemiological evidence establishes obesity as an independent risk factor for increased susceptibility and severity to viral respiratory pneumonias associated with H1N1 influenza and SARS-CoV-2 pandemics. Given the global obesity prevalence, a better understanding of the mechanisms behind obese susceptibility to infection is imperative. Altered immune cell metabolism and function are often perceived as a key causative factor of dysregulated inflammation. However, the contribution of adipocytes,
    Document: Epidemiological evidence establishes obesity as an independent risk factor for increased susceptibility and severity to viral respiratory pneumonias associated with H1N1 influenza and SARS-CoV-2 pandemics. Given the global obesity prevalence, a better understanding of the mechanisms behind obese susceptibility to infection is imperative. Altered immune cell metabolism and function are often perceived as a key causative factor of dysregulated inflammation. However, the contribution of adipocytes, the dominantly altered cell type in obesity with broad inflammatory properties, to infectious disease pathogenesis remains largely ignored. Thus, skewing of adipocyte-intrinsic cellular metabolism may lead to the development of pathogenic inflammatory adipocytes, which shape the overall immune responses by contributing to either premature immunosenescence, delayed hyperinflammation, or cytokine storm in infections. In this review, we discuss the underappreciated contribution of adipocyte cellular metabolism and adipocyte-produced mediators on immune system modulation and how such interplay may modify disease susceptibility and pathogenesis of influenza and SARS-CoV-2 infections in obese individuals.

    Search related documents:
    Co phrase search for related documents
    • acute phase and additional study: 1, 2
    • acute phase and adipose tissue: 1
    • acute phase and low grade inflammation: 1, 2
    • acute phase and lps response: 1, 2, 3
    • acute phase and lung damage: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20
    • acute phase and lung inflammatory: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14
    • acute phase and lung inflammatory response: 1, 2, 3
    • acute phase and lung tissue: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24
    • acute phase and lung tissue damage: 1, 2, 3, 4, 5
    • acute phase and macrophage infiltration: 1, 2, 3
    • acute phase and macrophage monocyte: 1, 2, 3
    • acute phase and macrophage secretion: 1
    • acute phase and macrophages m1: 1
    • acute phase and macrophages m1 phenotype: 1