Liver impairment in COVID-19 patients: a retrospective analysis of 115 cases from a single center in Wuhan city, China

Zhang, Yafei; Zheng, Liang; Liu, Lan; Zhao, Mengya; Xiao, Jun; Zhao, Qiu

BACKGROUND: The SARS-CoV-2 pandemic is an ongoing global health emergency The aim of our study was to investigate the changes of liver function and its clinical significance in COVID-19 patients METHOD: This retrospective, single-center study was conducted on 115 confirmed cases of COVID-19 in Zhongnan hospital of Wuhan University from Jan 18 to Feb 22, 2020 Liver function and related indexes were analyzed to evaluate its relationship with disease progression in COVID-19 patients RESULTS: Part of the COVID-19 patients presented with varying degrees of abnormality in liver function indexes However, the levels of ALT, AST, TBIL, GGT and LDH in COVID-19 patients were not significantly different in compared with hospitalized community-acquired pneumonia patients, and the levels of albumin is even significantly higher Levels of ALT, AST, TBIL, LDH and INR showed statistically significant elevation in severe COVID-19 cases compared with that in mild cases However, the clinical significance of the elevation is unremarkable Majority of severe COVID-19 patients showed significantly decreasing in albumin level and continuously decreasing in the progress of illness Most of the liver function indexes in COVID-19 patients were correlated with CRP and NLR, the markers of inflammation Logistic regression analysis further identified NLR as the independent risk factor for severe COVID-19, as well as age CONCLUSIONS: Although abnormalities of liver function indexes are common in COVID-19 patients, the impairment of liver function is not a prominent feature of COVID-19, and also may not have serious clinical consequences