High-resolution influenza mapping of a city reveals socioeconomic determinants of transmission within and between urban quarters

Adrian Egli; Nina Goldman; Nicola F. Müller; Myrta Brunner; Daniel Wüthrich; Sarah Tschudin-Sutter; Emma Hodcroft; Richard Neher; Claudia Saalfrank; James Hadfield; Trevor Bedford; Mohammedyaseen Syedbasha; Thomas Vogel; Noémie Augustin; Jan Bauer; Nadine Sailer; Nadezhda Amar-Sliwa; Daniela Lang; Helena M.B. Seth-Smith; Annette Blaich; Yvonne Hollenstein; Olivier Dubuis; Michael Nägele; Andreas Buser; Christian H. Nickel; Nicole Ritz; Andreas Zeller; Tanja Stadler; Manuel Battegay; Rita Schneider-Sliwa

For more detailed analyses, future studies would need to include hundreds of samples with high 321 resolution epidemiological data across multiple influenza seasons to study the changing patterns 322 of transmission over multiple years. In addition, the transmission events across urban quarters 323 . CC-BY-NC 4.0 International license author/funder. It is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.03.023135 doi: bioRxiv preprint are highly complex, driven by mobility of people living within a city and commuters, place of 324 working, and changing antibody titres of exposed patients in each year. Although we have asked 325 where a person works, we were not able to collect sufficient data for this question -only 24.6% 326 provided details and people working in the same statistical block were very rare (<5%).