Author: A. Reiser; D. Woschée; N. Mehrotra; R. Krzyszton; H. H. Strey; J. O. Rädler
Title: Correlation of mRNA delivery timing and protein expression in lipid-based transfection Document date: 2019_4_13
ID: 9h6ctbyx_9
Snippet: We use a kinetic biochemical rate model to describe mRNA expression to fit the individual single-cell time courses. The approach yields the individual kinetic rates and the time point when protein expression begins. As shown in Figure 2A our model includes translation of mRNA to protein and a subsequent chemical transition called maturation, which renders the GFP protein fluorescent (19, 20) . In addition, the model allows for degradation of both.....
Document: We use a kinetic biochemical rate model to describe mRNA expression to fit the individual single-cell time courses. The approach yields the individual kinetic rates and the time point when protein expression begins. As shown in Figure 2A our model includes translation of mRNA to protein and a subsequent chemical transition called maturation, which renders the GFP protein fluorescent (19, 20) . In addition, the model allows for degradation of both mRNA as well as protein with time. This translation-maturation model is formulated by a set of ordinary differential equations (ODEs). The initial conditions are given by the number of mRNA author/funder. All rights reserved. No reuse allowed without permission.
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