Author: Longlong Si; Haiqing Bai; Melissa Rodas; Wuji Cao; Crystal Yur Oh; Amanda Jiang; Atiq Nurani; Danni Y Zhu; Girija Goyal; Sarah Gilpin; Rachelle Prantil-Baun; Donald E. Ingber
Title: Human organs-on-chips as tools for repurposing approved drugs as potential influenza and COVID19 therapeutics in viral pandemics Document date: 2020_4_14
ID: mrgw2mnx_17
Snippet: When we added nafamostat or oseltamivir at different time points during influenza infection on-chip, both nafamostat and oseltamivir exhibited prophylactic and therapeutic effects (Fig. 3F) . However, the therapeutic effects of oseltamivir were detected only when it was administered within 48 h post-infection (Fig. 3F) . This is consistent with the observation that oseltamivir is only recommended for clinical use within 2 days of influenza infect.....
Document: When we added nafamostat or oseltamivir at different time points during influenza infection on-chip, both nafamostat and oseltamivir exhibited prophylactic and therapeutic effects (Fig. 3F) . However, the therapeutic effects of oseltamivir were detected only when it was administered within 48 h post-infection (Fig. 3F) . This is consistent with the observation that oseltamivir is only recommended for clinical use within 2 days of influenza infection 19 , which is one of the important limitations of this author/funder. All rights reserved. No reuse allowed without permission.
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