Selected article for: "chip organ and human organ"
Author: Longlong Si; Haiqing Bai; Melissa Rodas; Wuji Cao; Crystal Yur Oh; Amanda Jiang; Atiq Nurani; Danni Y Zhu; Girija Goyal; Sarah Gilpin; Rachelle Prantil-Baun; Donald E. Ingber
Title: Human organs-on-chips as tools for repurposing approved drugs as potential influenza and COVID19 therapeutics in viral pandemics
  • Document date: 2020_4_14
    • ID: mrgw2mnx_32
    Snippet: The ability to apply drugs using dynamic fluid flow also enables the cells to be treated with more clinically relevant dynamic drug exposures. While we administered drugs at their Cmax here to compare relative potencies, another caveat is that we did not quantify drug absorption or protein binding in this study. Importantly, by carrying out mass spectrometry measurements of drug levels in these devices, full PK profiles can be recapitulated in th.....
    Document: The ability to apply drugs using dynamic fluid flow also enables the cells to be treated with more clinically relevant dynamic drug exposures. While we administered drugs at their Cmax here to compare relative potencies, another caveat is that we did not quantify drug absorption or protein binding in this study. Importantly, by carrying out mass spectrometry measurements of drug levels in these devices, full PK profiles can be recapitulated in these Organ Chip models 8 , which should further aid clinical translation in the future. While animal models remain the benchmark for validation of therapeutics to move to humans, it is important to note that results from animal models are frequently wrong at predicting drug responses in human clinical trials 35,36 . In addition, human Organ Chips have been shown to recapitulate drug responses and toxicities observed in humans that could not be detected in animals 37, 38 . For these reasons, regulatory agencies are encouraging pharmaceutical and biotechnology companies to make use of data from Organ Chips and other microphysiological systems in their regulatory submissions 39 .

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