Human ACE2 receptor polymorphisms predict SARS-CoV-2 susceptibility

Eric W. Stawiski; Devan Diwanji; Kushal Suryamohan; Ravi Gupta; Frederic A. Fellouse; J. Fah Sathirapongsasuti; Jiang Liu; Ying-Ping Jiang; Aakrosh Ratan; Monika Mis; Devi Santhosh; Sneha Somasekar; Sangeetha Mohan; Sameer Phalke; Boney Kuriakose; Aju Antony; Jagath R. Junutula; Stephan C. Schuster; Natalia Jura; Somasekar Seshagiri

. CC-BY-NC-ND 4.0 International license author/funder. It is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.07.024752 doi: bioRxiv preprint polymorphic variation in human population were mapped on to the structure of the ACE2/SARS-CoV-2 RBD (PDB: 6VW1) and colored according to their effect on the predicted affinity between human ACE2 and viral spike S-protein systematically as measured by a deep sequence mutagenesis screen (Procko, 2020) . Polymorphisms that were predicted to enhance the binding between ACE2 and the S-protein are colored in magenta if they are located directly at the ACE2/SARS-CoV-2 interface or in light pink if they do not participate directly in the interface. Polymorphisms that are predicted to enhance the binding between ACE2 and the S-protein are colored in dark blue if they are located directly at the ACE2/SARS-CoV-2 interface or in light blue if they do not participate directly in the interface interactions.