Small nucleolar RNA host genes promoting epithelial-mesenchymal transition lead cancer progression and metastasis.

Biagioni, Alessio; Tavakol, Shima; Ahmadirad, Nooshin; Zahmatkeshan, Masoumeh; Magnelli, Lucia; Mandegary, Ali; Fekri, Hojjat Samareh; Asadi, Malek Hossein; Mohammadinejad, Reza; Ahn, Kwang Seok

The small nucleolar RNA host genes (SNHGs) belong to the long non-coding RNAs and are reported to be able to influence all three levels of cellular information-bearing molecules, i.e. DNA, RNA and proteins, resulting in the generation of complex phenomena. As the host genes of the small nucleolar RNAs (snoRNAs), they are commonly localized in the nucleolus, where they exert multiple regulatory functions orchestrating cellular homeostasis and differentiation as well as metastasis and chemoresistance. Indeed, worldwide literature has reported their involvement in the epithelial-mesenchymal transition (EMT) of different histotypes of cancer, being able to exploit peculiar features, for example, the possibility to act both in the nucleus and the cytoplasm. Moreover, SNHGs regulation is a fundamental topic to better understand their role in tumor progression albeit such mechanism is still debated. Here, we reviewed the biological functions of SNHGs in particular in the EMT process and discussed the perspectives for new cancer therapies. This article is protected by copyright. All rights reserved.