Selected article for: "nucleic acid and sample detect"
Author: Torres, Marcelo D.T.; de Araujo, William R.; de Lima, Lucas F.; Ferreira, André L.; de la Fuente-Nunez, Cesar
Title: Low-cost Biosensor for Rapid Detection of SARS-CoV-2 at the Point-of-Care
  • Cord-id: no9ch9nz
  • Document date: 2021_5_9
    • ID: no9ch9nz
    Snippet: SARS-CoV-2, the virus that causes COVID-19, has killed over 3 million people worldwide. Despite the urgency of the current pandemic, most available diagnostic methods for COVID-19 use RT-PCR to detect nucleic acid sequences specific to SARS-CoV-2. These tests are limited by their requirement of large laboratory space, high reagent costs, multistep sample preparations, and the potential for cross-contamination. Moreover, results usually take hours to days to become available. Therefore, fast, rel
    Document: SARS-CoV-2, the virus that causes COVID-19, has killed over 3 million people worldwide. Despite the urgency of the current pandemic, most available diagnostic methods for COVID-19 use RT-PCR to detect nucleic acid sequences specific to SARS-CoV-2. These tests are limited by their requirement of large laboratory space, high reagent costs, multistep sample preparations, and the potential for cross-contamination. Moreover, results usually take hours to days to become available. Therefore, fast, reliable, inexpensive, and scalable point-of-care diagnostics are urgently needed. Here, we describe RAPID 1.0, a simple, handheld, and highly sensitive miniaturized biosensor modified with human receptor angiotensin-converting enzyme-2 (ACE2) that can detect SARS-CoV-2 using 10 μL of sample within 4 minutes through its increased resistance to charge transfer of a redox probe measured by electrochemical impedance spectroscopy. The sensitivity and specificity of RAPID for nasopharyngeal/oropharyngeal swab and saliva samples are 85.3% and 100% and 100% and 86.5%, respectively.

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