Author: Longlong Si; Haiqing Bai; Melissa Rodas; Wuji Cao; Crystal Yur Oh; Amanda Jiang; Atiq Nurani; Danni Y Zhu; Girija Goyal; Sarah Gilpin; Rachelle Prantil-Baun; Donald E. Ingber
Title: Human organs-on-chips as tools for repurposing approved drugs as potential influenza and COVID19 therapeutics in viral pandemics Document date: 2020_4_14
ID: mrgw2mnx_23
Snippet: We therefore introduced CoV-2pp into the air channel of our highly differentiated human lung Airway Chips to mimic human infection by airborne SARS-CoV-2. High levels of the viral pol gene encoded by the CoV-2pp were detected in the lung airway epithelial cells in chips infected by CoV-2pp within 48 hours, but not in control chips that were inoculated with pseudoparticles without SARS-CoV-2 spike protein (Fig. S7) . This ability to efficiently in.....
Document: We therefore introduced CoV-2pp into the air channel of our highly differentiated human lung Airway Chips to mimic human infection by airborne SARS-CoV-2. High levels of the viral pol gene encoded by the CoV-2pp were detected in the lung airway epithelial cells in chips infected by CoV-2pp within 48 hours, but not in control chips that were inoculated with pseudoparticles without SARS-CoV-2 spike protein (Fig. S7) . This ability to efficiently infect human Airway Chips with CoV-2pp is consistent with our finding that these highly differentiated lung cells express high levels of its ACE2 author/funder. All rights reserved. No reuse allowed without permission.
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