Author: Bo Diao; Chenhui Wang; Rongshuai Wang; Zeqing Feng; Yingjun Tan; Huiming Wang; Changsong Wang; Liang Liu; Ying Liu; Yueping Liu; Gang Wang; Zilin Yuan; Liang Ren; Yuzhang Wu; Yongwen Chen
Title: Human Kidney is a Target for Novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection Document date: 2020_3_6
ID: bpnqz1cn_20
Snippet: As the deposition of the complement membrane-attack complex (MAC, also named C5b-9) on tubules or glomeruli may also cause renal damage, 14 we further analyzed C5b-9 status in kidney tissues from these postmortems. Interestingly, strong C5b-9 depositions on tubules were observed in all of these six cases. Very low levels of C5b-9 deposition on glomeruli and capillaries were also seen in two cases. However, C5b-9 expression is absent in normal kid.....
Document: As the deposition of the complement membrane-attack complex (MAC, also named C5b-9) on tubules or glomeruli may also cause renal damage, 14 we further analyzed C5b-9 status in kidney tissues from these postmortems. Interestingly, strong C5b-9 depositions on tubules were observed in all of these six cases. Very low levels of C5b-9 deposition on glomeruli and capillaries were also seen in two cases. However, C5b-9 expression is absent in normal kidney tissue ( Figure 4B , Table 2 ), suggesting that SARS-CoV-2 infection induces acute tubular necrosis and ARF through triggering C5b-9 deposition.
Search related documents:
Co phrase search for related documents- acute tubular necrosis and membrane attack: 1
- acute tubular necrosis and renal damage: 1, 2, 3, 4, 5
- complement MAC membrane attack complex and MAC membrane attack complex: 1, 2, 3, 4, 5
- complement MAC membrane attack complex and membrane attack: 1, 2, 3, 4, 5
- complement MAC membrane attack complex and membrane attack complex: 1, 2, 3, 4, 5
- complement MAC membrane attack complex deposition and MAC membrane attack complex: 1
- complement MAC membrane attack complex deposition and membrane attack: 1
- complement MAC membrane attack complex deposition and membrane attack complex: 1
- kidney tissue and low level: 1, 2
- kidney tissue and membrane attack: 1
- kidney tissue and renal damage: 1, 2, 3, 4, 5, 6, 7
- low level and renal damage: 1
- MAC membrane attack complex and membrane attack: 1, 2, 3, 4, 5, 6, 7, 8
- MAC membrane attack complex and membrane attack complex: 1, 2, 3, 4, 5, 6, 7, 8
Co phrase search for related documents, hyperlinks ordered by date