Selected article for: "attack complex and MAC attack complex"
Author: Bo Diao; Chenhui Wang; Rongshuai Wang; Zeqing Feng; Yingjun Tan; Huiming Wang; Changsong Wang; Liang Liu; Ying Liu; Yueping Liu; Gang Wang; Zilin Yuan; Liang Ren; Yuzhang Wu; Yongwen Chen
Title: Human Kidney is a Target for Novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection
  • Document date: 2020_3_6
    • ID: bpnqz1cn_20
    Snippet: As the deposition of the complement membrane-attack complex (MAC, also named C5b-9) on tubules or glomeruli may also cause renal damage, 14 we further analyzed C5b-9 status in kidney tissues from these postmortems. Interestingly, strong C5b-9 depositions on tubules were observed in all of these six cases. Very low levels of C5b-9 deposition on glomeruli and capillaries were also seen in two cases. However, C5b-9 expression is absent in normal kid.....
    Document: As the deposition of the complement membrane-attack complex (MAC, also named C5b-9) on tubules or glomeruli may also cause renal damage, 14 we further analyzed C5b-9 status in kidney tissues from these postmortems. Interestingly, strong C5b-9 depositions on tubules were observed in all of these six cases. Very low levels of C5b-9 deposition on glomeruli and capillaries were also seen in two cases. However, C5b-9 expression is absent in normal kidney tissue ( Figure 4B , Table 2 ), suggesting that SARS-CoV-2 infection induces acute tubular necrosis and ARF through triggering C5b-9 deposition.

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