Author: Austin Nguyen; Julianne K David; Sean K Maden; Mary A Wood; Benjamin R Weeder; Abhinav Nellore; Reid F Thompson
Title: Human leukocyte antigen susceptibility map for SARS-CoV-2 Document date: 2020_3_26
ID: k3y8tpps_2
Snippet: Human leukocyte antigen (HLA) alleles, which are critical components of the viral antigen presentation pathway, have been shown in previous studies to confer differential viral susceptibility and severity of disease. For instance, disease caused by the closely-related SARS-CoV (24, 25) shows increased severity among individuals with the HLA-B*46:01 genotype (1) . Associations between HLA genotype and disease severity extend broadly to several oth.....
Document: Human leukocyte antigen (HLA) alleles, which are critical components of the viral antigen presentation pathway, have been shown in previous studies to confer differential viral susceptibility and severity of disease. For instance, disease caused by the closely-related SARS-CoV (24, 25) shows increased severity among individuals with the HLA-B*46:01 genotype (1) . Associations between HLA genotype and disease severity extend broadly to several other unrelated viruses. For example, in human immunodeficiency virus 1 (HIV-1), certain HLA types (e.g. HLA-A*02:05) may reduce risk of seroconversion (50) , and in dengue virus, certain HLA alleles (e.g. HLA-A*02:07, HLA-B*51) are associated with increased secondary disease severity among ethnic Thais (51) .
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