Selected article for: "complete loss and gene expression"
Author: Jun Wu; Dingyun Song; Zhongwen Li; Baojie Guo; Yani Xiao; Wenjing Liu; Lingmin Liang; Chunjing Feng; Tingting Gao; Zai Wang; Jianyan Wen; Shengnan Yang; Peipei Liu; Lei Wang; Yukai Wang; Liang Peng; Guihai Feng; Shiqiang Huang; Glyn Nigel Stacey; Wei Li; Yan Huo; Ronghua Jin; Qi Zhou; Liu Wang; Baoyang Hu; Huaping Dai; Jie Hao
Title: Immunity-and-Matrix-Regulatory Cells Derived from Human Embryonic Stem Cells Safely and Effectively Treat Mouse Lung Injury and Fibrosis
  • Document date: 2020_4_16
    • ID: 8dpla6jt_47
    Snippet: To elucidate the heterogeneity of gene expression amongst IMRCs, single cell RNA sequencing 401 (scRNAseq) was performed for both IMRCs and primary UCMSCs. Our scRNAseq data also showed 402 that IMRCs were relatively homogenous in expression for the MSC-specific markers PDGFRA, SPARC, 403 NT5E, ITGB1 and ENG. IMRCs were also relatively homogenous in their suppression of pluripotency 404 and non-mesenchymal markers, relative to hESCs and UCMSCs, s.....
    Document: To elucidate the heterogeneity of gene expression amongst IMRCs, single cell RNA sequencing 401 (scRNAseq) was performed for both IMRCs and primary UCMSCs. Our scRNAseq data also showed 402 that IMRCs were relatively homogenous in expression for the MSC-specific markers PDGFRA, SPARC, 403 NT5E, ITGB1 and ENG. IMRCs were also relatively homogenous in their suppression of pluripotency 404 and non-mesenchymal markers, relative to hESCs and UCMSCs, suggesting they are likely to be similar 405 in biological activity to primary MSCs after transplantation (Fig. 2F) . These results provided insight into 406 the clinical applicability of IMRCs, especially with regards to their complete loss of pluripotency and 407 their gain in hyper-immunomodulatory potential. 408

    Search related documents:
    Co phrase search for related documents
    • biological activity and insight provide: 1, 2, 3, 4
    • clinical applicability and gene expression: 1, 2, 3, 4, 5
    • clinical applicability and insight provide: 1, 2
    • complete loss and gene expression: 1, 2, 3, 4, 5
    • gene expression and insight provide: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • gene expression and primary msc: 1
    • insight provide and result insight provide: 1, 2, 3, 4, 5, 6