Author: Edison Ong; Mei U Wong; Anthony Huffman; Yongqun He
Title: COVID-19 coronavirus vaccine design using reverse vaccinology and machine learning Document date: 2020_3_21
ID: ld0vo1rl_10
Snippet: Among the five non-structural proteins being predicted as potential vaccine candidates, the 236 nsp3 protein was predicted to have second-highest protective antigenicity score, adhesin property, 237 promiscuous MHC-I & MHC-II T cell epitopes, and B cell epitopes. The nsp3 is the largest non-238 structural protein that includes multiple functional domains related to viral pathogenesis 29 . The 239 multiple sequence alignment of nsp3 also showed hi.....
Document: Among the five non-structural proteins being predicted as potential vaccine candidates, the 236 nsp3 protein was predicted to have second-highest protective antigenicity score, adhesin property, 237 promiscuous MHC-I & MHC-II T cell epitopes, and B cell epitopes. The nsp3 is the largest non-238 structural protein that includes multiple functional domains related to viral pathogenesis 29 . The 239 multiple sequence alignment of nsp3 also showed higher sequence conservation in most of the 240 functional domains in SARS-CoV-2, SARS-CoV, and MERS-CoV, than in all 15 coronavirus 241 strains (Fig. 1B) . Besides the nsp3 protein, our study also predicted four additional non-structural 242 proteins (3CL-pro, nsp8, nsp9, and nsp10) as possible vaccine candidates based on their adhesin 243 probabilities, and the nsp8 protein was also predicted to have a significant protective antigenicity 244 score. 245
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