Author: Huan Ma; Weihong Zeng; Hongliang He; Dan Zhao; Yunru Yang; Dehua Jiang; Peigen Zhou; Yingjie Qi; Weihuang He; Changcheng Zhao; Ruting Yi; Xiaofang Wang; Bo Wang; Yuanhong Xu; Yun Yang; Arnaud John Kombe Kombe; Chengchao Ding; Jiajia Xie; Yong Gao; Linzhao Cheng; Yajuan Li; Xiaoling Ma; Tengchuan Jin
Title: COVID-19 diagnosis and study of serum SARS-CoV-2 specific IgA, IgM and IgG by a quantitative and sensitive immunoassay Document date: 2020_4_22
ID: 4jeaqqn9_44
Snippet: Our serological kits have overall good performance 326 Our kits have much higher accuracy than RT-qPCR (sensitivity less than 70%) for detecting viral 327 RNA 9-13 , and published immune-assays such as " flow immunoassay" and ELISA in earlier studies 10-12, 328 17-21, 23, 24 . When we combined RBD-specific IgA and IgG kits together, the sensitivity, specificity and 329 overall agreement elevate to 99· 1%, 100%, and 99· 7%, respectively (table 1.....
Document: Our serological kits have overall good performance 326 Our kits have much higher accuracy than RT-qPCR (sensitivity less than 70%) for detecting viral 327 RNA 9-13 , and published immune-assays such as " flow immunoassay" and ELISA in earlier studies 10-12, 328 17-21, 23, 24 . When we combined RBD-specific IgA and IgG kits together, the sensitivity, specificity and 329 overall agreement elevate to 99· 1%, 100%, and 99· 7%, respectively (table 1). In addition, this RBD-330 based detection kit may also help to screen and detect neutralization antibodies targeting SARS-CoV-2 331 RBD, because this peptide domain is exposed on viral surface and functions as a ligand binding to the 332 host cell surface receptor ACE2.
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