Selected article for: "IgG production and relatively high sensitivity"
Author: Huan Ma; Weihong Zeng; Hongliang He; Dan Zhao; Yunru Yang; Dehua Jiang; Peigen Zhou; Yingjie Qi; Weihuang He; Changcheng Zhao; Ruting Yi; Xiaofang Wang; Bo Wang; Yuanhong Xu; Yun Yang; Arnaud John Kombe Kombe; Chengchao Ding; Jiajia Xie; Yong Gao; Linzhao Cheng; Yajuan Li; Xiaoling Ma; Tengchuan Jin
Title: COVID-19 diagnosis and study of serum SARS-CoV-2 specific IgA, IgM and IgG by a quantitative and sensitive immunoassay
  • Document date: 2020_4_22
    • ID: 4jeaqqn9_50
    Snippet: Although one serum collected at the 4th day after illness onset was diagnosed as positive by our IgM 336 kit (not IgA or IgG kits in this study), the IgM kit overall showed a lower diagnostic specificity of 92· 3% 337 compared to that of IgG and IgA (figure 1). IgM is known to have relatively lower affinity toward 338 antigens compared with that of IgG or IgA. In addition, IgM often causes false positive signals as we 339 also observed (suppleme.....
    Document: Although one serum collected at the 4th day after illness onset was diagnosed as positive by our IgM 336 kit (not IgA or IgG kits in this study), the IgM kit overall showed a lower diagnostic specificity of 92· 3% 337 compared to that of IgG and IgA (figure 1). IgM is known to have relatively lower affinity toward 338 antigens compared with that of IgG or IgA. In addition, IgM often causes false positive signals as we 339 also observed (supplemental table 2), due to its pentameric structure 34 . To the contrary, IgA or IgG 340 antibody does not have this problem. Our RBD-specific IgG kit showed high specificity of 99· 8% (figure 341 1) but relatively low sensitivity of 96· 8%. This is expected, because that most (6/7) false negative cases 342 were samples collected at 4-10 days after illness onset when IgG production is likely very low.

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