Author: Song, Fuhang; Yang, Na; Khalil, Zeinab G; Salim, Angela A; Han, Jiahui; Bernhardt, Paul V; Lin, Rui; Xu, Xiuli; Capon, Robert J
Title: Bhimamycin J, a rare benzo[f]isoindole-dione alkaloid from the marine-derived actinomycete Streptomyces sp. MS180069. Cord-id: lmbregtw Document date: 2021_10_5
ID: lmbregtw
Snippet: Chemical investigation on a Streptomyces sp. strain MS180069 isolated from a sediment sample collected from the South China Sea, yielded the new benzo[f]isoindole-dione alkaloid, bhimamycin J ( 1 ). The structure was determined by extensive spectroscopic analysis, including HRMS, 1D, 2D NMR, and X-ray diffraction techniques. A molecular docking study revealed 1 as a new molecular motif that binds with human angiotensin converting enzyme2 (ACE2), recently described as the cell surface receptor re
Document: Chemical investigation on a Streptomyces sp. strain MS180069 isolated from a sediment sample collected from the South China Sea, yielded the new benzo[f]isoindole-dione alkaloid, bhimamycin J ( 1 ). The structure was determined by extensive spectroscopic analysis, including HRMS, 1D, 2D NMR, and X-ray diffraction techniques. A molecular docking study revealed 1 as a new molecular motif that binds with human angiotensin converting enzyme2 (ACE2), recently described as the cell surface receptor responsible for uptake of 2019-CoV-2. Using enzyme assays we confirm that 1 inhibits human ACE2 79.7% at 25 m g/mL.
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