Selected article for: "acute treatment and low resource"
Author: Longlong Si; Haiqing Bai; Melissa Rodas; Wuji Cao; Crystal Yur Oh; Amanda Jiang; Atiq Nurani; Danni Y Zhu; Girija Goyal; Sarah Gilpin; Rachelle Prantil-Baun; Donald E. Ingber
Title: Human organs-on-chips as tools for repurposing approved drugs as potential influenza and COVID19 therapeutics in viral pandemics
  • Document date: 2020_4_14
    • ID: mrgw2mnx_37
    Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.13.039917 doi: bioRxiv preprint artesunate. Thus, amodiaquine could be explored in the near-term as a potential acute therapeutic treatment agent against COVID19 in nations where this drug is more readily available, and it may be particularly valuable in Africa and other low resource nations where supplies of more expensive alternative th.....
    Document: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.13.039917 doi: bioRxiv preprint artesunate. Thus, amodiaquine could be explored in the near-term as a potential acute therapeutic treatment agent against COVID19 in nations where this drug is more readily available, and it may be particularly valuable in Africa and other low resource nations where supplies of more expensive alternative therapies are limited. Toremifene, on the other hand, has been shown to be a relatively well tolerated chronic treatment (> 5 years) for breast cancer in males as well as females, and thus could be considered for both prophylaxis and treatment of COVID19 454 . Given the alarming rate at which the pandemic is spreading, clinicians should seriously consider the relative risks and benefits of using any existing approved drug as a new COVID19 therapy before initiating any trial in their local communities.

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