Author: Longlong Si; Haiqing Bai; Melissa Rodas; Wuji Cao; Crystal Yur Oh; Amanda Jiang; Atiq Nurani; Danni Y Zhu; Girija Goyal; Sarah Gilpin; Rachelle Prantil-Baun; Donald E. Ingber
Title: Human organs-on-chips as tools for repurposing approved drugs as potential influenza and COVID19 therapeutics in viral pandemics Document date: 2020_4_14
ID: mrgw2mnx_38
Snippet: The current COVID19 pandemic and past ones caused by influenza, represent imminent dangers and major ongoing public health concerns. Repurposing existing antiviral agents using multiplexed simple cell-based assays in combination with lower throughput/higher content, human Organ Chips that recapitulate human-relevant responses, rather than animal models that often do not faithfully recapitulate human symptoms, could provide a fast track to potenti.....
Document: The current COVID19 pandemic and past ones caused by influenza, represent imminent dangers and major ongoing public health concerns. Repurposing existing antiviral agents using multiplexed simple cell-based assays in combination with lower throughput/higher content, human Organ Chips that recapitulate human-relevant responses, rather than animal models that often do not faithfully recapitulate human symptoms, could provide a fast track to potential treatments for the current COVID19 pandemic, and be equally valuable against unforeseen biothreats in the future. There have been multiple recent reports that identify other approved drugs that similarly have the potential to act as COVID19 therapeutics 14, 40, 41, 46 ; however, to our knowledge, none of these recommendations are based on results of responses of highly differentiated human lung epithelial cells exposed to drugs under dynamic flow conditions that more closely mimic clinically relevant blood exposures as we did here. Given their ability to recapitulate tissue-tissue interfaces, recruitment of circulating immune cells, cytokine author/funder. All rights reserved. No reuse allowed without permission.
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