Author: wei zhao; Nian liu; Xiao Li Tao; Chun hong Zheng; Xiang yu Li; Man Yu; Yong gang Li
Title: Host protein CD63 enhances viral RNA replication by interacting with human astrovirus nonstructural protein nsP1a/4 Document date: 2018_5_27
ID: 8r1zb4oc_1
Snippet: showed that nsP1a/4 and CD63 co-localized in the cytoplasm of infected cells. 28 Over expression of CD63 promoted viral RNA synthesis, whereas knockdown 29 of CD63 markedly decreased viral RNA levels. Those results suggest that CD63 30 plays a critical role in human astrovirus RNA replication. The interaction 31 between CD63 and nsP1a/4 provides a channel to further understand the roles of 32 interactions between host and virus proteins in astrov.....
Document: showed that nsP1a/4 and CD63 co-localized in the cytoplasm of infected cells. 28 Over expression of CD63 promoted viral RNA synthesis, whereas knockdown 29 of CD63 markedly decreased viral RNA levels. Those results suggest that CD63 30 plays a critical role in human astrovirus RNA replication. The interaction 31 between CD63 and nsP1a/4 provides a channel to further understand the roles of 32 interactions between host and virus proteins in astrovirus infection and release. Human astroviruses cause gastroenteritis in young children and 36 immunocompromised patients. In this study, we provide evidence that nsP1a/4, 37 author/funder. All rights reserved. No reuse allowed without permission.
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