Selected article for: "cell type and Murine norovirus"
Author: Hsu, Charlie C.; Meeker, Stacey M.; Escobar, Sabine; Brabb, Thea L.; Paik, Jisun; Park, Heon; Iritani, Brian M.; Maggio-Price, Lillian
Title: Murine norovirus inhibits B cell development in the bone marrow of STAT1-deficient mice
  • Cord-id: xalq6kub
  • Document date: 2018_2_1
    • ID: xalq6kub
    Snippet: Noroviruses are a leading cause of gastroenteritis in humans and it was recently revealed that noroviruses can infect B cells. We demonstrate that murine norovirus (MNV) infection can significantly impair B cell development in the bone marrow in a signal transducer and activator of transcription 1 (STAT1) dependent, but interferon signaling independent manner. We also show that MNV replication is more pronounced in the absence of STAT1 in ex vivo cultured B cells. Interestingly, using bone marro
    Document: Noroviruses are a leading cause of gastroenteritis in humans and it was recently revealed that noroviruses can infect B cells. We demonstrate that murine norovirus (MNV) infection can significantly impair B cell development in the bone marrow in a signal transducer and activator of transcription 1 (STAT1) dependent, but interferon signaling independent manner. We also show that MNV replication is more pronounced in the absence of STAT1 in ex vivo cultured B cells. Interestingly, using bone marrow transplantation studies, we found that impaired B cell development requires Stat1(−/−) hematopoietic cells and Stat1(−/−) stromal cells, and that the presence of wild-type hematopoietic or stromal cells was sufficient to restore normal development of Stat1(−/−) B cells. These results suggest that B cells normally restrain norovirus replication in a cell autonomous manner, and that wild-type STAT1 is required to protect B cell development during infection.

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