Author: Ben Longdon; Jonathan P Day; Joel M Alves; Sophia CL Smith; Thomas M Houslay; John E McGonigle; Lucia Tagliaferri; Francis M Jiggins
Title: Host shifts result in parallel genetic changes when viruses evolve in closely related species Document date: 2017_11_28
ID: ithoxu6k_23
Snippet: where viruses tend to replicate more rapidly when the new host is related to the pathogens natural The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/226175 doi: bioRxiv preprint 7 acquired adaptations to their host species that benefitted them when they infected closely related 161 species. Our results demonstrate that this pattern is apparent at the level of specific nucleotides, 162 and can ar.....
Document: where viruses tend to replicate more rapidly when the new host is related to the pathogens natural The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/226175 doi: bioRxiv preprint 7 acquired adaptations to their host species that benefitted them when they infected closely related 161 species. Our results demonstrate that this pattern is apparent at the level of specific nucleotides, 162 and can arise very shortly after a host shift. The function of these mutations is unknown, but in other 163 systems adaptations after host shifts have been found to enhance the ability of the virus to bind to 164 host receptors [11] , increase replication rates [16] or avoid the host immune response [8, 10, 45] .
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