Selected article for: "RT PCR kit and target gene"
Author: Bal, Antonin; Destras, Gregory; Gaymard, Alexandre; Stefic, Karl; Marlet, Julien; Eymieux, Sébastien; Regue, Hadrien; Semanas, Quentin; d’Aubarede, Constance; Billaud, Geneviève; Laurent, Frédéric; Gonzalez, Claudia; Mekki, Yahia; Valette, Martine; Bouscambert, Maude; Gaudy-Graffin, Catherine; Lina, Bruno; Morfin, Florence; Josset, Laurence; Casalegno, Jean-Sébastien; Frobert, Emilie; Escuret, Vanessa; Icard, Vinca; Jeannoel, Marion; Milon, Marie-Paule; Ramière, Christophe; Scholtès, Caroline; Tardy, Jean-Claude; Trabaud, Mary-Anne; Schuffenecker, Isabelle
Title: Two-step strategy for the identification of SARS-CoV-2 variant of concern 202012/01 and other variants with spike deletion H69–V70, France, August to December 2020
  • Cord-id: aeqhdu9f
  • Document date: 2021_1_21
    • ID: aeqhdu9f
    Snippet: We report the strategy leading to the first detection of variant of concern 202012/01 (VOC) in France (21 December 2020). First, the spike (S) deletion H69–V70 (ΔH69/ΔV70), identified in certain SARS-CoV-2 variants including VOC, is screened for. This deletion is associated with a S-gene target failure (SGTF) in the three-target RT-PCR assay (TaqPath kit). Subsequently, SGTF samples are whole genome sequenced. This approach revealed mutations co-occurring with ΔH69/ΔV70 including S:N501Y i
    Document: We report the strategy leading to the first detection of variant of concern 202012/01 (VOC) in France (21 December 2020). First, the spike (S) deletion H69–V70 (ΔH69/ΔV70), identified in certain SARS-CoV-2 variants including VOC, is screened for. This deletion is associated with a S-gene target failure (SGTF) in the three-target RT-PCR assay (TaqPath kit). Subsequently, SGTF samples are whole genome sequenced. This approach revealed mutations co-occurring with ΔH69/ΔV70 including S:N501Y in the VOC.

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