Selected article for: "clinical relevance and disease severity"

Author: Sette, Alessandro; Crotty, Shane
Title: Pre-existing immunity to SARS-CoV-2: the knowns and unknowns
  • Cord-id: bw6a5gmy
  • Document date: 2020_7_7
  • ID: bw6a5gmy
    Snippet: T cell reactivity against SARS-CoV-2 was observed in unexposed people; however, the source and clinical relevance of the reactivity remains unknown. It is speculated that this reflects T cell memory to circulating ‘common cold’ coronaviruses. It will be important to define specificities of these T cells and assess their association with COVID-19 disease severity and vaccine responses.
    Document: T cell reactivity against SARS-CoV-2 was observed in unexposed people; however, the source and clinical relevance of the reactivity remains unknown. It is speculated that this reflects T cell memory to circulating ‘common cold’ coronaviruses. It will be important to define specificities of these T cells and assess their association with COVID-19 disease severity and vaccine responses.

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