Selected article for: "RNA virus and virus perform"
Author: François Ferron; Humberto Julio Debat; Etienne Decroly; Bruno Canard
Title: Identification of a Nidovirales Orf1a N7-guanine cap Methyltransferase signature-sequence as a genetic marker of large genome Tobaniviridae
  • Document date: 2019_5_17
    • ID: lnf2mj29_28
    Snippet: RNA virus cap-MTases perform two types of reactions: the methylation of the N7-guanine of the RNA cap, and the methylation of the adenosine 2'-O ribose of the first transcribed nucleotide [6] . Regarding the guanine methylation, this reaction can also be achieved on a GTP molecule before capping, in some virus families, and the N7-methyl GTP is then used to cap the RNA [42] . This is the case with the alphavirus nsp1 enzyme, whose structure is cu.....
    Document: RNA virus cap-MTases perform two types of reactions: the methylation of the N7-guanine of the RNA cap, and the methylation of the adenosine 2'-O ribose of the first transcribed nucleotide [6] . Regarding the guanine methylation, this reaction can also be achieved on a GTP molecule before capping, in some virus families, and the N7-methyl GTP is then used to cap the RNA [42] . This is the case with the alphavirus nsp1 enzyme, whose structure is currently unknown. Conversely, several crystal structures of viral enzymes involved in N7guanine methylation of RNA caps have been reported, such as that of flaviviruses (NS5, [43] ), rotaviruses and reoviruses (VP4 and lambda2, respectively [38, 39] ), and coronaviruses (nsp14, [11, 12] ).

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