Author: Sangeun Jeon; Meehyun Ko; Jihye Lee; Inhee Choi; Soo Young Byun; Soonju Park; David Shum; Seungtaek Kim
Title: Identification of antiviral drug candidates against SARS-CoV-2 from FDA-approved drugs Document date: 2020_3_20
ID: 5f95gve3_10
Snippet: The confocal microscope images of both viral N protein and cell nuclei were analyzed using our in-house Image Mining (IM) software and the dose-response curve (DRC) for each drug was generated ( Figure 1 ). Chloroquine, lopinavir, and remdesivir were used as reference drugs with IC 50 values of 9.12, 7.28, and 11.41 µM, respectively ( Figure 1A ). Among the 48 drugs that were evaluated in our study, 24 drugs showed potential antiviral activities.....
Document: The confocal microscope images of both viral N protein and cell nuclei were analyzed using our in-house Image Mining (IM) software and the dose-response curve (DRC) for each drug was generated ( Figure 1 ). Chloroquine, lopinavir, and remdesivir were used as reference drugs with IC 50 values of 9.12, 7.28, and 11.41 µM, respectively ( Figure 1A ). Among the 48 drugs that were evaluated in our study, 24 drugs showed potential antiviral activities against SARS-CoV-2 with IC 50 values in between 0.1 and 10 µM; Tilorone, Cyclosporine, Loperamide, Mefloquine, Amodiaquine, Proscillaridin, Digitoxin, Digoxin, Hexachlorophene, Hydroxyprogesterone caproate, Salinomycin, Ouabain, Cepharanthine, Ciclesonide, Oxyclozanide, Anidulafungin, Gilteritinib, Berbamine, Tetrandrine, Abemaciclib, Ivacaftor, Bazedoxifene, Niclosamide, and Eltrombopag.
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