Author: Sangeun Jeon; Meehyun Ko; Jihye Lee; Inhee Choi; Soo Young Byun; Soonju Park; David Shum; Seungtaek Kim
Title: Identification of antiviral drug candidates against SARS-CoV-2 from FDA-approved drugs Document date: 2020_3_20
ID: 5f95gve3_12
Snippet: corroborated our finding of ciclesonide as a potential antiviral drug against SARS-CoV-2 12 . A treatment report of three patients who were infected by SARS-CoV-2 in Japan (https://www3.nhk.or.jp/nhkworld/en/news/20200303_20/) warrants further clinical investigation of this drug in patients with COVID-19. Intriguingly, an underlying mechanism for the suppression of viral infection by ciclesonide has been revealed by the isolation of a drug-resist.....
Document: corroborated our finding of ciclesonide as a potential antiviral drug against SARS-CoV-2 12 . A treatment report of three patients who were infected by SARS-CoV-2 in Japan (https://www3.nhk.or.jp/nhkworld/en/news/20200303_20/) warrants further clinical investigation of this drug in patients with COVID-19. Intriguingly, an underlying mechanism for the suppression of viral infection by ciclesonide has been revealed by the isolation of a drug-resistant mutant 12 . The isolation of the drug-resistant mutant indicated that NSP15, a viral riboendonuclease, is the molecular target of ciclesonide. Together, it is not unreasonable to consider that ciclesonide exhibits a direct-acting antiviral activity in addition to its intrinsic antiinflammatory function. In the future, siRNA targeting the hormone receptor will allow to assess the extent of direct-acting antiviral activity. With its proven anti-inflammatory activity, author/funder. All rights reserved. No reuse allowed without permission.
Search related documents:
Co phrase search for related documents- anti inflammatory activity and molecular target: 1
- anti inflammatory activity and SARS infect: 1
- anti inflammatory activity and viral infection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20
- antiviral activity and clinical investigation: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13
- antiviral activity and direct act: 1, 2
- antiviral activity and drug clinical investigation: 1, 2
- antiviral activity and drug resistant mutant: 1
- antiviral activity and molecular target: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18
- antiviral activity and SARS infect: 1, 2, 3, 4
- antiviral activity and treatment report: 1
- antiviral activity and viral infection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76
- antiviral drug and clinical investigation: 1, 2, 3, 4, 5, 6, 7
- antiviral drug and drug clinical investigation: 1, 2
- antiviral drug and drug resistant mutant: 1
- antiviral drug and molecular target: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
- antiviral drug and SARS infect: 1, 2, 3, 4, 5, 6, 7, 8
- antiviral drug and treatment report: 1, 2, 3
- antiviral drug and viral infection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74
Co phrase search for related documents, hyperlinks ordered by date