Author: Liangzhong Lim; Amrita Roy; Jianxing Song
Title: Identification of a Zika NS2B-NS3pro pocket susceptible to allosteric inhibition by small molecules including qucertin rich in edible plants Document date: 2016_10_1
ID: gfiukh90_4
Snippet: Zika genome is translated into a single ~3,500-residue polyprotein, which is further cleaved into 3 structural proteins and 7 non-structural proteins (11) . The correct processing of the polyprotein is essential for replication of all flaviviruses, which requires both host proteases and a viral NS2B-NS3 protease (NS2B-NS3pro) (11) (12) (13) (14) (15) (16) (17) (18) . As a consequence, the flaviviral NS2B-NS3pro has been well-established to be key.....
Document: Zika genome is translated into a single ~3,500-residue polyprotein, which is further cleaved into 3 structural proteins and 7 non-structural proteins (11) . The correct processing of the polyprotein is essential for replication of all flaviviruses, which requires both host proteases and a viral NS2B-NS3 protease (NS2B-NS3pro) (11) (12) (13) (14) (15) (16) (17) (18) . As a consequence, the flaviviral NS2B-NS3pro has been well-established to be key targets for developing antiviral drugs (11) (12) (13) (14) (15) (16) (17) (18) . In particular, the unique concern on the vaccine treatment to Zika and Dengue strongly author/funder. All rights reserved. No reuse allowed without permission.
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