Author: Sangeun Jeon; Meehyun Ko; Jihye Lee; Inhee Choi; Soo Young Byun; Soonju Park; David Shum; Seungtaek Kim
Title: Identification of antiviral drug candidates against SARS-CoV-2 from FDA-approved drugs Document date: 2020_3_20
ID: 5f95gve3_11
Snippet: Among these 24 drugs, two FDA-approved drugs drew our attention. First, niclosamide, an antihelminthic drug, exhibited very potent antiviral activity against SARS-CoV-2 (IC 50 = 0.28 µM). Not surprisingly, its broad-spectrum antiviral effect has been well documented in the Second, ciclesonide is another interesting drug candidate for further development although its antiviral potency was much lower (IC 50 = 4.33 µM) than niclosamide. It is an i.....
Document: Among these 24 drugs, two FDA-approved drugs drew our attention. First, niclosamide, an antihelminthic drug, exhibited very potent antiviral activity against SARS-CoV-2 (IC 50 = 0.28 µM). Not surprisingly, its broad-spectrum antiviral effect has been well documented in the Second, ciclesonide is another interesting drug candidate for further development although its antiviral potency was much lower (IC 50 = 4.33 µM) than niclosamide. It is an inhaled corticosteroid used to treat asthma and allergic rhinitis 11 . A recent report by Matsuyama et al.
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