Author: Hema Kothari; Corey M. Williams; Chantel McSkimming; Mythili Vigneshwar; Eli R. Zunder; Coleen A. McNamara
Title: Identification of Human Immune Cell Subtypes Most Vulnerable to IL-1ß-induced Inflammatory Signaling Using Mass Cytometry Document date: 2020_4_19
ID: 5rhn7gom_37
Snippet: IL-1β is an apical proinflammatory cytokine that exacerbates inflammation through activating both innate and adaptive immune cells and production of a variety of proinflammatory cytokines and chemokines. Indeed, induction of p-STAT1, p-STAT3 and p-STAT5 expression across multiple immune cell subtypes after prolonged IL-1β stimulation indicates signaling mediated by secondary mediators such as IL-6, IFN-γ, IL-17A. Robust induction of p-NF-kB ex.....
Document: IL-1β is an apical proinflammatory cytokine that exacerbates inflammation through activating both innate and adaptive immune cells and production of a variety of proinflammatory cytokines and chemokines. Indeed, induction of p-STAT1, p-STAT3 and p-STAT5 expression across multiple immune cell subtypes after prolonged IL-1β stimulation indicates signaling mediated by secondary mediators such as IL-6, IFN-γ, IL-17A. Robust induction of p-NF-kB expression in the CCR6 + EM T cells, CD11c mDC and the Lin -CD161 + CD25 + cells indicate that these cell types may play an important upstream role in IL-1β-mediated inflammation including cytokine storm. author/funder. All rights reserved. No reuse allowed without permission.
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