Author: Ostrovskii, Vladimir Ð.; Danagulyan, Gevorg G.; Nesterova, Olga M.; Pavlyukova, Yulia N.; Tolstyakov, Vladimir V.; Zarubina, Olga S.; Slepukhin, Pavel Ð.; Esaulkova, Yana L.; Muryleva, Anna Ð.; Zarubaev, Vladimir V.; Trifonov, Rostislav E.
Title: Synthesis and antiviral activity of nonannulated tetrazolylpyrimidines Cord-id: nn9bpm26 Document date: 2021_5_14
ID: nn9bpm26
Snippet: [Image: see text] Nonannulated tetrazolylpyrimidines in the structure of which the heterocyclic fragments are separated by hydrazinocarbonylmethyl, methylpyrazolyl groups or a sulfur atom were synthesized. Some of these compounds showed moderate in vitro activity against H1N1 subtype of influenza A virus. The selectivity index of the anti-influenza action of {5-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]-1H-tetrazol-1-yl}acetic acid, which has very low cytotoxicity, was twice as high as the selectivi
Document: [Image: see text] Nonannulated tetrazolylpyrimidines in the structure of which the heterocyclic fragments are separated by hydrazinocarbonylmethyl, methylpyrazolyl groups or a sulfur atom were synthesized. Some of these compounds showed moderate in vitro activity against H1N1 subtype of influenza A virus. The selectivity index of the anti-influenza action of {5-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]-1H-tetrazol-1-yl}acetic acid, which has very low cytotoxicity, was twice as high as the selectivity index of the reference drug rimantadine.
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