Author: Wen Wen; Wenru Su; Hao Tang; Wenqing Le; Xiaopeng Zhang; Yingfeng Zheng; XiuXing Liu; Lihui Xie; Jianmin Li; Jinguo Ye; Xiuliang Cui; Yushan Miao; Depeng Wang; Jiantao Dong; Chuan-Le Xiao; Wei Chen; Hongyang Wang
Title: Immune Cell Profiling of COVID-19 Patients in the Recovery Stage by Single-Cell Sequencing Document date: 2020_3_27
ID: 8aezcyf9_28
Snippet: TCR-seq analysis showed that T cell expansion was obviously decreased in the ERS group than in the HC group (Fig. 4G ). Moreover, naïve or central memory T cells showed little clonal expansion, while effector memory T cells, terminal effector CD8 + T cells (CTLs), and proliferating T cells showed higher expansion levels (Fig. 4H ). In addition, the most highly expanded (maximum) clone in the ERS group was TRAV8-6-TRAJ45:TRAV7-8-TRBJ2-1 (Fig. S5D.....
Document: TCR-seq analysis showed that T cell expansion was obviously decreased in the ERS group than in the HC group (Fig. 4G ). Moreover, naïve or central memory T cells showed little clonal expansion, while effector memory T cells, terminal effector CD8 + T cells (CTLs), and proliferating T cells showed higher expansion levels (Fig. 4H ). In addition, the most highly expanded (maximum) clone in the ERS group was TRAV8-6-TRAJ45:TRAV7-8-TRBJ2-1 (Fig. S5D ). The decreased ratio of CD8 + T cells in COVID-19 patients may implicate the role of CD8 + T cells in virus clearance (Fig. 4C ). Moreover, the CD8 + CTL with expanded clones also exhibited overactivated inflammation and antiviral activity compared to those in HCs ( Fig. 4I and Fig. S4B ). Together, these findings show that clonally expanded CD8 + T cells in the peripheral blood of COVID-19 patients help control the virus.
Search related documents:
Co phrase search for related documents- antiviral activity and decreased ratio: 1
- antiviral activity and peripheral blood: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20
- antiviral activity and virus clearance: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
- antiviral activity and virus control: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39
- cell expansion and central memory: 1, 2, 3, 4, 5
- cell expansion and clonal expansion: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39
- cell expansion and ERS group: 1
- cell expansion and expansion level: 1
- cell expansion and little clonal expansion: 1, 2
- cell expansion and peripheral blood: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21
- cell expansion and TCR seq: 1
- cell expansion and virus clearance: 1, 2, 3, 4, 5
- cell expansion and virus control: 1, 2, 3, 4
- central memory and clonal expansion: 1, 2, 3, 4, 5
- central memory and expansion level: 1
- central memory and high expansion level: 1
- central memory and little clonal expansion: 1
- central memory and peripheral blood: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
- central memory and TCR seq: 1
Co phrase search for related documents, hyperlinks ordered by date