Author: Saba Ismail; Sajjad Ahmad; Syed Sikander Azam
Title: Immuno-informatics Characterization SARS-CoV-2 Spike Glycoprotein for Prioritization of Epitope based Multivalent Peptide Vaccine Document date: 2020_4_12
ID: 3jmo35jc_74
Snippet: Taken together, we characterized SARS-CoV-2 spike glycoprotein for antigenic peptides and proposed a MEPVC by means of several computational immunological methods and biophysical calculations. The outcomes of this study could save time and associated cost that go into experimental epitope targets study. The MEPVC is capable of activating all components of the host immune system, have suitable structural and physicochemical properties. Also, it se.....
Document: Taken together, we characterized SARS-CoV-2 spike glycoprotein for antigenic peptides and proposed a MEPVC by means of several computational immunological methods and biophysical calculations. The outcomes of this study could save time and associated cost that go into experimental epitope targets study. The MEPVC is capable of activating all components of the host immune system, have suitable structural and physicochemical properties. Also, it seems to have very stable dynamics with TLR3 innate immune receptor and thus has higher chances of presentation to the host immune system. However, additional in vivo and in vitro experimentations are needed to disclose its potential in fight against COVID-19.
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