Author: Lilei Yu; Yongqing Tong; Gaigai Shen; Aisi Fu; Yanqiu Lai; Xiaoya Zhou; Yuan Yuan; Yuhong Wang; Yuchen Pan; Zhiyao Yu; Yan Li; Tiangang Liu; Hong Jiang
Title: Immunodepletion with Hypoxemia: A Potential High Risk Subtype of Coronavirus Disease 2019 Document date: 2020_3_6
ID: 5imbomop_8
Snippet: Host immune response is essential for the clearance of coronavirus infection, and the balance between coronavirus and host immunity is key to viral pathogenesis and will ultimately determine infection outcome 1 . Coronaviruses encode numerous viral gene products to evade and suppress host immune response, such as SARS-associated coronavirus nonstructural protein 1, which is able to inhibit host interferon-dependent antiviral signaling 2 , as well.....
Document: Host immune response is essential for the clearance of coronavirus infection, and the balance between coronavirus and host immunity is key to viral pathogenesis and will ultimately determine infection outcome 1 . Coronaviruses encode numerous viral gene products to evade and suppress host immune response, such as SARS-associated coronavirus nonstructural protein 1, which is able to inhibit host interferon-dependent antiviral signaling 2 , as well as another SARS coronavirus protein named open reading frame-9b, which can suppress mitochondria of immune cells 3 . Coronavirus suppressing host immunity has been demonstrated, however, the alterations of immune system in patients with COVID-2019 are not yet well understood.
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