Author: Dan Zhang; Rui Guo; Lei Lei; Hongjuan Liu; Yawen Wang; Yili Wang; Tongxin Dai; Tianxiao Zhang; Yanjun Lai; Jingya Wang; Zhiqiang Liu; Aili He; Michael O'Dwyer; Jinsong Hu
Title: COVID-19 infection induces readily detectable morphological and inflammation-related phenotypic changes in peripheral blood monocytes, the severity of which correlate with patient outcome Document date: 2020_3_26
ID: nlavfnpt_19
Snippet: To validate the nature of the FSC-high population, we further performed Wright-Giemsa staining on blood smears. As shown in Figure 1D , we confirmed the presence of an increased number of larger, atypical, vacuolated monocytes, not normally seen in the peripheral blood of healthy individuals. Table 1 , shows that while the total number of monocytes/macrophages in the peripheral did not differ between patients and a healthy donor, there was an i.....
Document: To validate the nature of the FSC-high population, we further performed Wright-Giemsa staining on blood smears. As shown in Figure 1D , we confirmed the presence of an increased number of larger, atypical, vacuolated monocytes, not normally seen in the peripheral blood of healthy individuals. Table 1 , shows that while the total number of monocytes/macrophages in the peripheral did not differ between patients and a healthy donor, there was an increased proportion of activated monocytes/macrophages in patients with COVID-19.
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