Selected article for: "acute disease and creatine kinase"
Author: Nakamura, Yoshihiko; Katano, Harutaka; Nakajima, Noriko; Sato, Yuko; Suzuki, Tadaki; Sekizuka, Tsuyoshi; Kuroda, Makoto; Izutani, Yoshito; Morimoto, Shinichi; Maruyama, Junichi; Koie, Megumi; Kitamura, Taisuke; Ishikura, Hiroyasu
Title: SARS-CoV-2 is localized in cardiomyocytes: a post-mortem biopsy case
  • Cord-id: an9ipcaf
  • Document date: 2021_8_9
    • ID: an9ipcaf
    Snippet: A 72-year-old patient was admitted to the ICU due to acute respiratory distress syndrome caused by coronavirus disease 2019. On day 20, the patient experienced shock. The electrocardiogram showed ST segment elevation in leads V3–V6 and severe left ventricular dysfunction with an ejection fraction of 35%–40%. The left ventricle showed basal hypokinesis and apical akinesis, while the creatine kinase level was normal, indicating Takotsubo cardiomyopathy. On day 24, the patient died of multiple
    Document: A 72-year-old patient was admitted to the ICU due to acute respiratory distress syndrome caused by coronavirus disease 2019. On day 20, the patient experienced shock. The electrocardiogram showed ST segment elevation in leads V3–V6 and severe left ventricular dysfunction with an ejection fraction of 35%–40%. The left ventricle showed basal hypokinesis and apical akinesis, while the creatine kinase level was normal, indicating Takotsubo cardiomyopathy. On day 24, the patient died of multiple organ failure. In post-mortem biopsy, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigen was detected in cardiomyocytes by immunostaining. Moreover, SARS-CoV-2 RNA was detected in heart tissue. We need to further analyze the direct link between SARS-CoV2 and cardiomyocytes.

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