Author: Rashmi Mohanty; Xinquan Liu; Jae You Kim; Xiujuan Peng; Sahil Bhandari; Jasmim Leal; Dhivya Arasappan; Dennis C. Wylie; Tony Dong; Debadyuti Ghosh
Title: Identification of peptide coatings that enhance diffusive transport of nanoparticles through the tumor microenvironment Document date: 2019_6_4
ID: e2uzk4u1_41
Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. . https://doi.org/10.1101/659524 doi: bioRxiv preprint amino acid residue of the P4 sequence and (2) place the acidic and basic residues adjacent to each other ( Table 2c ). The net charge and hydrophobicity of the mutant sequences remain the same as the original sequence. From diffusion assays, the original selected sequence exhibits three-fold and two-fol.....
Document: The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. . https://doi.org/10.1101/659524 doi: bioRxiv preprint amino acid residue of the P4 sequence and (2) place the acidic and basic residues adjacent to each other ( Table 2c ). The net charge and hydrophobicity of the mutant sequences remain the same as the original sequence. From diffusion assays, the original selected sequence exhibits three-fold and two-fold higher effective diffusivity compared to the interchanged and adjacent mutants, respectively (Figure 4c) . This result suggests that the order of the amino acid sequence significantly impacts the diffusivity through the tumor-like ECM. Others have previously shown that modifying the spatial configuration of charge modulates the transport of peptides through a mucin hydrogel 63
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