Selected article for: "ECM extracellular matrix and extracellular matrix"
Author: Rashmi Mohanty; Xinquan Liu; Jae You Kim; Xiujuan Peng; Sahil Bhandari; Jasmim Leal; Dhivya Arasappan; Dennis C. Wylie; Tony Dong; Debadyuti Ghosh
Title: Identification of peptide coatings that enhance diffusive transport of nanoparticles through the tumor microenvironment
  • Document date: 2019_6_4
    • ID: e2uzk4u1_7
    Snippet: For successful delivery and efficacy of therapeutics in solid tumors, it is critical for drugs to reach as many target cells as possible to improve their therapeutic index and minimize drug resistance 1 . Increasing penetration of antibodies [2] [3] [4] , small molecule drugs [5] [6] [7] [8] , and nanoparticles [9] [10] [11] [12] through the tumor microenvironment improves drug distribution, achieves tumor regression and significantly improves th.....
    Document: For successful delivery and efficacy of therapeutics in solid tumors, it is critical for drugs to reach as many target cells as possible to improve their therapeutic index and minimize drug resistance 1 . Increasing penetration of antibodies [2] [3] [4] , small molecule drugs [5] [6] [7] [8] , and nanoparticles [9] [10] [11] [12] through the tumor microenvironment improves drug distribution, achieves tumor regression and significantly improves the therapeutic index of these compounds. The transport of these molecules through the heterogeneous tumor microenvironment significantly depends on their physicochemical properties and their interactions with the tumor extracellular matrix (ECM) 13 .

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