Author: Wylezich, Claudia; Schaller, Tina; Claus, Rainer; Hirschbühl, Klaus; Märkl, Bruno; Kling, Elisabeth; Spring, Oliver; Höper, Dirk; Schlegel, Jürgen; Beer, Martin; Dintner, Sebastian
Title: Whole-genome analysis of SARS-CoV-2 samples indicate no tissue specific genetic adaptation of the virus in COVID-19 patients’ upper and lower respiratory tract Cord-id: c8tiioy8 Document date: 2021_8_20
ID: c8tiioy8
Snippet: Sample panels of SARS-CoV-2 cases were retrospectively whole-genome sequenced. In three individuals, samples of upper and lower respiratory tract resulted in identical sequences suggesting virus stability including the spike protein cleavage site. In a fourth case, low-level intra-host genomic evolution and a unique 5-nucleotide deletion was observed.
Document: Sample panels of SARS-CoV-2 cases were retrospectively whole-genome sequenced. In three individuals, samples of upper and lower respiratory tract resulted in identical sequences suggesting virus stability including the spike protein cleavage site. In a fourth case, low-level intra-host genomic evolution and a unique 5-nucleotide deletion was observed.
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