Author: Wen Wen; Wenru Su; Hao Tang; Wenqing Le; Xiaopeng Zhang; Yingfeng Zheng; XiuXing Liu; Lihui Xie; Jianmin Li; Jinguo Ye; Xiuliang Cui; Yushan Miao; Depeng Wang; Jiantao Dong; Chuan-Le Xiao; Wei Chen; Hongyang Wang
Title: Immune Cell Profiling of COVID-19 Patients in the Recovery Stage by Single-Cell Sequencing Document date: 2020_3_27
ID: 8aezcyf9_42
Snippet: An established computational approach [17] was used to predict cell-to-cell interactions that may contribute to the distinct functional state of T cells, B cells, monocytes, and dendritic cells (DCs) in ERS and LRS (Fig. 7A, B) . In ERS COVID-19 patients, we found adaptive signals involved in monocyte activation, proliferation, and inflammatory signaling (Fig. 7A, B) . T cells expressed genes encoding ligands of TNFSF8, LTA, IFNG, IL17A, CCR5, an.....
Document: An established computational approach [17] was used to predict cell-to-cell interactions that may contribute to the distinct functional state of T cells, B cells, monocytes, and dendritic cells (DCs) in ERS and LRS (Fig. 7A, B) . In ERS COVID-19 patients, we found adaptive signals involved in monocyte activation, proliferation, and inflammatory signaling (Fig. 7A, B) . T cells expressed genes encoding ligands of TNFSF8, LTA, IFNG, IL17A, CCR5, and LTB to TNFRSF8, TNFRSF1A/TNFRSF14, IFNGR1, IL-17RA, CCR1, and LTBR, which were expressed on monocytes and could contribute to the pro-inflammatory status. Other T cell-monocyte interactions involved the expression of CSF2 and CSF1. T cells might activate monocytes through the expression of CSF2 and CSF1, which bind to CSFRs (CSFR2/1) and contribute to inflammatory storm. A cluster All rights reserved. No reuse allowed without permission.
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