Author: Wen Wen; Wenru Su; Hao Tang; Wenqing Le; Xiaopeng Zhang; Yingfeng Zheng; XiuXing Liu; Lihui Xie; Jianmin Li; Jinguo Ye; Xiuliang Cui; Yushan Miao; Depeng Wang; Jiantao Dong; Chuan-Le Xiao; Wei Chen; Hongyang Wang
Title: Immune Cell Profiling of COVID-19 Patients in the Recovery Stage by Single-Cell Sequencing Document date: 2020_3_27
ID: 8aezcyf9_4
Snippet: Immune system dysregulation, such as lymphopenia and inflammatory cytokine storm, have been observed and are believed to be associated with the severity of pathogenic coronavirus infections, such as severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) infections [12, 13] . With regard to COVID-19, recent studies also found decreases in lymphocyte numbers and increases in serum inflam.....
Document: Immune system dysregulation, such as lymphopenia and inflammatory cytokine storm, have been observed and are believed to be associated with the severity of pathogenic coronavirus infections, such as severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) infections [12, 13] . With regard to COVID-19, recent studies also found decreases in lymphocyte numbers and increases in serum inflammatory cytokine levels in peripheral blood [5, 14] . However, the manner in which key immune cell subsets change and their states during COVID-19 have remained largely unclear. Thus, defining these key cellular subsets and their states in COVID-19 is a crucial step in obtaining critical insights into the immune clearance mechanism and developing new therapeutic strategies for COVID-19.
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