Author: Lee, Nelson; Wong, Chun Kwok; Chan, Paul K S; Lindegardh, Niklas; White, Nicholas J; Hayden, Frederick G; Wong, Edward H C; Wong, Ka Shing; Cockram, Clive S; Sung, Joseph J Y; Hui, David S C
Title: Acute encephalopathy associated with influenza A infection in adults. Cord-id: atvp9s88 Document date: 2010_1_1
ID: atvp9s88
Snippet: We report acute encephalopathy associated with influenza A infection in 3 adults. We detected high cerebrospinal fluid (CSF) and plasma concentrations of CXCL8/IL-8 and CCL2/MCP-1 (CSF/plasma ratios > or =3), and interleukin-6, CXCL10/IP-10, but no evidence of viral neuroinvasion. Patients recovered without sequelae. Hyperactivated cytokine response may play a role in pathogenesis.
Document: We report acute encephalopathy associated with influenza A infection in 3 adults. We detected high cerebrospinal fluid (CSF) and plasma concentrations of CXCL8/IL-8 and CCL2/MCP-1 (CSF/plasma ratios > or =3), and interleukin-6, CXCL10/IP-10, but no evidence of viral neuroinvasion. Patients recovered without sequelae. Hyperactivated cytokine response may play a role in pathogenesis.
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