Author: Arévalos, Victor; Ortega-Paz, Luis; RodrÃguez-Arias, Juan José; Calvo, Margarita; Castrillo, Leticia; Salazar, Anthony; Roque, Merce; Dantas, Ana Paula; Sabaté, Manel; Brugaletta, Salvatore
Title: Myocardial Injury in COVID-19 Patients: Association with Inflammation, Coagulopathy and In-Hospital Prognosis Cord-id: cdqjf9lw Document date: 2021_5_13
ID: cdqjf9lw
Snippet: The exact mechanisms leading to myocardial injury in the coronavirus disease 2019 (COVID-19) are still unknown. In this retrospective observational study, we include all consecutive COVID-19 patients admitted to our center. They were divided into two groups according to the presence of myocardial injury. Clinical variables, Charlson Comorbidity Index (CCI), C-reactive protein (CRP), CAC (COVID-19-associated coagulopathy), defined according to the ISTH score, treatment and in-hospital events were
Document: The exact mechanisms leading to myocardial injury in the coronavirus disease 2019 (COVID-19) are still unknown. In this retrospective observational study, we include all consecutive COVID-19 patients admitted to our center. They were divided into two groups according to the presence of myocardial injury. Clinical variables, Charlson Comorbidity Index (CCI), C-reactive protein (CRP), CAC (COVID-19-associated coagulopathy), defined according to the ISTH score, treatment and in-hospital events were collected. Between March and April 2020, 331 COVID-19 patients were enrolled, 72 of them (21.8%) with myocardial injury. Patients with myocardial injury showed a higher CCI score (median (interquartile range), 5 (4–7) vs. 2 (1–4), p = 0.001), higher CRP values (18.3 (9.6–25.9) mg/dL vs. 12.0 (5.4–19.4) mg/dL, p ˂ 0.001) and CAC score (1 (0–2) vs. 0 (0–1), p = 0.001), and had lower use of any anticoagulant (57 patients (82.6%) vs. 229 patients (90.9%), p = 0.078), than those without. In the adjusted logistic regression, CRP, myocardial injury, CCI and CAC score were positive independent predictors of mortality, whereas anticoagulants resulted as a protective factor. Myocardial injury in COVID-19 patients is associated with inflammation and coagulopathy, resulting in a worse in-hospital prognosis. Treatment with anticoagulant agents may help to improve in-hospital outcomes.
Search related documents:
Co phrase search for related documents- absolute number and acute coronary syndrome: 1, 2, 3
- absolute number and acute respiratory syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18
- absolute number and admission rate: 1, 2
- absolute number and local regulation: 1
- absolute number and logistic analysis: 1
- absolute number and logistic regression: 1, 2, 3, 4, 5
- absolute number and logistic regression analysis: 1
- absolute number and low incidence: 1
- absolute number and low mortality: 1, 2, 3
- academic barc research consortium and acs acute coronary syndrome: 1, 2
- academic barc research consortium and acute coronary syndrome: 1, 2, 3
- acs acute coronary syndrome and acute coronary syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- acs acute coronary syndrome and acute respiratory syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16
- acs acute coronary syndrome and admission rate: 1, 2, 3
- acs acute coronary syndrome and logistic analysis: 1, 2, 3
- acs acute coronary syndrome and logistic regression: 1, 2, 3, 4, 5, 6
- acs acute coronary syndrome and logistic regression analysis: 1, 2, 3
- acs acute coronary syndrome and low incidence: 1, 2, 3
- acs acute coronary syndrome and low mortality: 1, 2, 3, 4
Co phrase search for related documents, hyperlinks ordered by date