Author: Jun Wu; Dingyun Song; Zhongwen Li; Baojie Guo; Yani Xiao; Wenjing Liu; Lingmin Liang; Chunjing Feng; Tingting Gao; Zai Wang; Jianyan Wen; Shengnan Yang; Peipei Liu; Lei Wang; Yukai Wang; Liang Peng; Guihai Feng; Shiqiang Huang; Glyn Nigel Stacey; Wei Li; Yan Huo; Ronghua Jin; Qi Zhou; Liu Wang; Baoyang Hu; Huaping Dai; Jie Hao
Title: Immunity-and-Matrix-Regulatory Cells Derived from Human Embryonic Stem Cells Safely and Effectively Treat Mouse Lung Injury and Fibrosis Document date: 2020_4_16
ID: 8dpla6jt_54
Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.15.042119 doi: bioRxiv preprint 6), IL-1b, tumor necrosis factor alpha (TNF-a), GRO-a, IFN-a2, IL-1a, IL-3, and IL-8 ( Fig. 3G and 427 Fig. S3 ). Furthermore, while the anti-inflammatory IL-4 was lower, the immunomodulatory cytokines 428 IL-1RA, LIF, and RANTES were higher in IMRCs than UCMSCs (Fig. 3H) . Amongst the pro-429 regenerative .....
Document: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.15.042119 doi: bioRxiv preprint 6), IL-1b, tumor necrosis factor alpha (TNF-a), GRO-a, IFN-a2, IL-1a, IL-3, and IL-8 ( Fig. 3G and 427 Fig. S3 ). Furthermore, while the anti-inflammatory IL-4 was lower, the immunomodulatory cytokines 428 IL-1RA, LIF, and RANTES were higher in IMRCs than UCMSCs (Fig. 3H) . Amongst the pro-429 regenerative cytokines, we found that GM-CSF was similar while VEGFA, MIG and SDF-1a were higher 430 in IMRCs than UCMSCs (Fig. 3I) . These results indicate that IMRCs manifest much stronger 431 immunomodulatory and pro-regenerative functions than UCMSCs. 432
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