Author: Jun Wu; Dingyun Song; Zhongwen Li; Baojie Guo; Yani Xiao; Wenjing Liu; Lingmin Liang; Chunjing Feng; Tingting Gao; Zai Wang; Jianyan Wen; Shengnan Yang; Peipei Liu; Lei Wang; Yukai Wang; Liang Peng; Guihai Feng; Shiqiang Huang; Glyn Nigel Stacey; Wei Li; Yan Huo; Ronghua Jin; Qi Zhou; Liu Wang; Baoyang Hu; Huaping Dai; Jie Hao
Title: Immunity-and-Matrix-Regulatory Cells Derived from Human Embryonic Stem Cells Safely and Effectively Treat Mouse Lung Injury and Fibrosis Document date: 2020_4_16
ID: 8dpla6jt_57
Snippet: Immunofluorescence and western blot analyses confirmed that TGF-β1 induced the upregulation of 445 collagen I and the downregulation of E-cadherin (Fig. 4H, I) . These results indicated that the A549 446 alveolar epithelial cells could simulate lung fibrosis in vitro. Thereafter, A549 cells were cultured with 447 or without the conditioned media of IMRCs, along with TGF-β1 treatment. Our results showed that the 448 IMRCs conditioned media signi.....
Document: Immunofluorescence and western blot analyses confirmed that TGF-β1 induced the upregulation of 445 collagen I and the downregulation of E-cadherin (Fig. 4H, I) . These results indicated that the A549 446 alveolar epithelial cells could simulate lung fibrosis in vitro. Thereafter, A549 cells were cultured with 447 or without the conditioned media of IMRCs, along with TGF-β1 treatment. Our results showed that the 448 IMRCs conditioned media significantly ameliorated the induction of Collagen I expression (Fig. 4J) . 449
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